ASEC became the first qualifiers for the quarter-finals by beating Jwaneng 3-0 in Abidjan, and Simba will be join them if they can secure four more points.
Decisive ASEC Mimosa , whose lone Champions League title came 25 years ago, boast a nursery that has produced many players who went on to achieve fame in Europe, like the Toure brothers Yaya and Kolo.
Among the stars of the current side is Sankara Karamoko, who scored his fourth goal of the campaign to complete a decisive victory over Jwaneng, who stunned Wydad in matchday one.
Leibe Avo gave the Abidjan outfit an early lead, Essis Aka scored on 80 minutes and Karamoko netted in added time.
Victories for TP Mazembe from the Democratic Republic of Congo and Mamelodi Sundowns of South Africa moved them three points above Nouadhibou of Mauritania and Pyramids of Egypt in Group A.
Brazilian Lucas Ribeiro set up Teboho Mokoena to fire a low shot into the corner of the net after 17 minutes and give former champions Sundowns a 1-0 win over Pyramids in Cairo.
Five-time title-holders Mazembe left it late against Nouadhibou in Lubumbashi with 19-year-old Malian Cheick Fofana scoring after 80 minutes and again in added time for a 2-0 victory.
Petro Luanda let slip a chance to qualify from Group C after drawing 0-0 at home against four-time champions Esperance of Tunisia, but they remain first, and likely quarter-finalists.