Zambian international Emmanuel Mayuka scored his second goal for Zamalek but his goal that restored a first half parity did not help Zamalek as they lost 3-1 at the Petrosport stadium in Cairo.
The host drew first blood in the 16th minute before the Zambian goal poacher who has rediscovered his form drew level ten minutes later for a 1-1 half time score line.
On resumption El Entaq had Louay Badri sent off in the first minute of the second half after picking a second yellow card. salah Amin extended the hosts lead in the 71st minute before Mahmoud Fathallah scored the third via the spot beyond reach of Zamalek.
The loss is a set back for Zamalek who had hoped to keep pressure on leaders AL Ahly. AL Masri crushed ENPPI 4-0 to moved to within six points of leaders AL Ahly who are top on 44 points and two points behind second placed Zamalek.