SuperSport United welcome the Absa Premiership Limpopo Province-based outfit Baroka FC in a crucial encounter in Johannesburg.
Baroka are going into this match highly motivated following their 1-0 victory against contenders Mamelodi Sundowns FC on the weekend.
On the other hand, the home side will be looking to regain their glory after losing 2-1 to Orlando Pirates on Saturday afternoon at the Emirates Airline Park.
The loss saw them dropping from position three to number four on the league table.
Matsatsantsa are still aiming to finish the league in the top three bracket with two matches remaining.
Their last match will be played against Cape Town City FC this coming Saturday at the Tshwane’s Loftus Versfeld Stadium.
The match is scheduled for Bidvest Stadium on Wednesday evening with kickoff set for 18:00 CAT (19:00 EAT)