The White Knights of Egypt scored twice in each half against Morocco’s Rouges et Blancs to grab a first-leg advantage at home.
The home side took an early lead through Mohamed Shikabala who scored with a stunning long range shot to make it 1-0 to Zamalek in the fourth minute.
It was soon 2-0 to Zamalek in the 18th minute following a defensive error by Wydad and Ayman Hefny was there to double the home side’s lead.
The White Knights were leading 2-0 during the half-time break.
Bassem Morsi extended Zamalek’s lead to 3-0 just three minutes into the second-half as the home side continued to dominate the first-leg encounter.
With eighteen minutes left on the clock, Zamalek were awarded a penalty. Second-half substitute Mostafa Fathi sealed Zamalek’s 4-0 victory.
Wydad will host Zamalek in the second-leg encounter at the Stade de FUS in the Moroccan city of Rabat on Saturday, 24 September 2016.
Zamalek (2) 4 (Shikabala 4′, Hefny 18′, Morsi 48′, Fathi 72′)
Wydad (0) 0
Zamalek: Ahmed El-Shennawi; Ahmed Tawfik, Eslam Gamal, Ali Gabr, Ramzi Khaled; Tarek Hamed, Ibrahim Salah, Maarouf Yussuf, Ayman Hefny, Mahmoud ‘Shikabala’ Abdel-Razek, Bassem Morsi
Wydad Casablanca: Mohamed Akid; Mourtada Fall, Youssef Rabeh, Abdellatif Noussir, Yassine El Kordy, Salaheddine Saidi, Brahim Nekkach, Walid El Karti, Reda Hajhouj, Nguessi Ondama, Ismail El Haddad
