The game will be used to commemorate the 2018 Simba Day Celebrations.
Simba Day is celebrated annually by the Tanzanian outfit to unveil new players and award outstanding ones.
Asante Kotoko are expected to leave the country next week for the game.
A message from the club’s official twitter handle read,”Asante Kotoko will be travelling to Tanzania to play Simba SC on Wednesday 8th, August, 2018 in honour of their Simba Day celebration.”
The MTN FA holders have recently been engaged in low profile friendly matches to stay fit and in good match condition.
On Sunday, 29th, July, 2018, they beat Susubiribi United Football Club 1-0 in an Ohum Special cup match at the Old Tafo Rovers Park in Koforidua.
There is uncertainty surrounding the return of the Zylofon Cash Premier League after the ex-Ghana Football Association (GFA) boss Kwesi Nyantekyi and some officiating officials were caught in a video done by Ghanaian undercover journalist Anas Aremeyaw Anas for receiving bribe to influence outcome of games and offer players game time in the national teams.